G70R (p.Gly70Arg) variant of ICOS (Inducible T-cell costimulator)
G70R (p.Gly70Arg) in ICOS (Inducible T-cell costimulator) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
G70R (p.Gly70Arg) variant details
- p.Gly70Arg
- NCI-TCGA Cosmic COSV5703
- cosmic curated COSV57031
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.221
- REVEL 0.04
- MetaLR 0.08
- MetaSVM -1.03
- CADD 17.20
- PolyPhen-2 0.33
- SIFT 0.07
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available