G58R (p.Gly58Arg) variant of ICOS (Inducible T-cell costimulator)
G58R (p.Gly58Arg) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, published literature, and structural context.
G58R (p.Gly58Arg) variant details
- p.Gly58Arg
- gnomAD 2-203955749-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.384
- REVEL 0.15
- MetaLR 0.15
- MetaSVM -0.78
- CADD 25.60
- PolyPhen-2 0.82
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available