G4D (p.Gly4Asp) variant of ICOS (Inducible T-cell costimulator)
G4D (p.Gly4Asp) in ICOS (Inducible T-cell costimulator) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
G4D (p.Gly4Asp) variant details
- p.Gly4Asp
- rs1363456237
- TOPMed rs1363456237
- gnomAD rs1363456237
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0948
- REVEL 0.05
- MetaLR 0.02
- MetaSVM -1.00
- CADD 1.07
- PolyPhen-2 0.00
- SIFT 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available