G37S (p.Gly37Ser) variant of ICOS (Inducible T-cell costimulator)
G37S (p.Gly37Ser) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
G37S (p.Gly37Ser) variant details
- p.Gly37Ser
- 1000Genomes rs539709751
- ExAC rs539709751
- gnomAD rs539709751
- Missense
- Variant Prioritization Score for Impact Estimate 0.34
- REVEL 0.22
- MetaLR 0.14
- MetaSVM -0.90
- CADD 24.10
- PolyPhen-2 1.00
- SIFT 0.08
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available