G37R (p.Gly37Arg) variant of ICOS (Inducible T-cell costimulator)
G37R (p.Gly37Arg) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
G37R (p.Gly37Arg) variant details
- p.Gly37Arg
- 1000Genomes rs539709751
- ExAC rs539709751
- gnomAD rs539709751
- Missense
- Variant Prioritization Score for Impact Estimate 0.357
- REVEL 0.25
- MetaLR 0.18
- MetaSVM -0.83
- CADD 24.30
- PolyPhen-2 1.00
- SIFT 0.04
- Most common in the 1KG:ESN population (allele frequency 0.0049)
- Structural context available