G36R (p.Gly36Arg) variant of ICOS (Inducible T-cell costimulator)
G36R (p.Gly36Arg) in ICOS (Inducible T-cell costimulator) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided; Immunodeficiency, common variable, 1. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
G36R (p.Gly36Arg) variant details
- p.Gly36Arg
- rs202109644
- ClinGen CA2067224
- ClinVar RCV001064716
- ClinVar RCV001815468
- Uncertain significance
- not provided; Immunodeficiency, common variable, 1
- Missense
- Variant Prioritization Score for Impact Estimate 0.44
- REVEL 0.32
- MetaLR 0.20
- MetaSVM -0.75
- CADD 26.00
- PolyPhen-2 1.00
- SIFT 0.04
- ClinVar: Uncertain significance (not provided; Immunodeficiency, common variable, 1)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00066)
- Structural context available