G24S (p.Gly24Ser) variant of ICOS (Inducible T-cell costimulator)
G24S (p.Gly24Ser) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, published literature, and structural context.
G24S (p.Gly24Ser) variant details
- p.Gly24Ser
- gnomAD 2-203955647-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.205
- REVEL 0.06
- MetaLR 0.05
- MetaSVM -1.08
- CADD 19.90
- PolyPhen-2 0.16
- SIFT 0.25
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available