G24R (p.Gly24Arg) variant of ICOS (Inducible T-cell costimulator)
G24R (p.Gly24Arg) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
G24R (p.Gly24Arg) variant details
- p.Gly24Arg
- gnomAD 2-203955647-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.213
- REVEL 0.04
- MetaLR 0.10
- MetaSVM -1.06
- CADD 22.80
- PolyPhen-2 0.67
- SIFT 0.21
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available