F51Y (p.Phe51Tyr) variant of ICOS (Inducible T-cell costimulator)
F51Y (p.Phe51Tyr) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
F51Y (p.Phe51Tyr) variant details
- p.Phe51Tyr
- ExAC rs769205363
- TOPMed rs769205363
- gnomAD rs769205363
- Missense
- Variant Prioritization Score for Impact Estimate 0.225
- REVEL 0.08
- MetaLR 0.06
- MetaSVM -1.04
- CADD 22.90
- PolyPhen-2 0.01
- SIFT 0.03
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available