F51L (p.Phe51Leu) variant of ICOS (Inducible T-cell costimulator)
F51L (p.Phe51Leu) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, published literature, and structural context.
F51L (p.Phe51Leu) variant details
- p.Phe51Leu
- gnomAD 2-203955728-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.194
- REVEL 0.08
- MetaLR 0.04
- MetaSVM -1.05
- CADD 20.50
- PolyPhen-2 0.00
- SIFT 0.24
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available