D64Y (p.Asp64Tyr) variant of ICOS (Inducible T-cell costimulator)
D64Y (p.Asp64Tyr) in ICOS (Inducible T-cell costimulator) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
D64Y (p.Asp64Tyr) variant details
- p.Asp64Tyr
- gnomAD rs1215466849
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.197
- REVEL 0.03
- MetaLR 0.13
- MetaSVM -1.03
- CADD 22.50
- PolyPhen-2 0.91
- SIFT 0.05
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available