D64H (p.Asp64His) variant of ICOS (Inducible T-cell costimulator)
D64H (p.Asp64His) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, published literature, and structural context.
D64H (p.Asp64His) variant details
- p.Asp64His
- gnomAD 2-203955767-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.205
- REVEL 0.05
- MetaLR 0.13
- MetaSVM -1.03
- CADD 22.20
- PolyPhen-2 0.87
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available