D46Y (p.Asp46Tyr) variant of ICOS (Inducible T-cell costimulator)
D46Y (p.Asp46Tyr) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
D46Y (p.Asp46Tyr) variant details
- p.Asp46Tyr
- gnomAD rs1229656377
- Missense
- Variant Prioritization Score for Impact Estimate 0.255
- REVEL 0.07
- MetaLR 0.09
- MetaSVM -1.06
- CADD 23.20
- PolyPhen-2 0.66
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available