D46N (p.Asp46Asn) variant of ICOS (Inducible T-cell costimulator)
D46N (p.Asp46Asn) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, published literature, and structural context.
D46N (p.Asp46Asn) variant details
- p.Asp46Asn
- gnomAD 2-203955713-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.241
- REVEL 0.06
- MetaLR 0.06
- MetaSVM -1.05
- CADD 21.50
- PolyPhen-2 0.17
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available