D46G (p.Asp46Gly) variant of ICOS (Inducible T-cell costimulator)
D46G (p.Asp46Gly) in ICOS (Inducible T-cell costimulator) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
D46G (p.Asp46Gly) variant details
- p.Asp46Gly
- NCI-TCGA Cosmic COSV1003
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.248
- REVEL 0.02
- MetaLR 0.06
- MetaSVM -0.99
- CADD 14.90
- PolyPhen-2 0.09
- SIFT 0.08
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available