D46E (p.Asp46Glu) variant of ICOS (Inducible T-cell costimulator)
D46E (p.Asp46Glu) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data and structural context.
D46E (p.Asp46Glu) variant details
- p.Asp46Glu
- ExAC rs780725264
- gnomAD rs780725264
- Missense
- Variant Prioritization Score for Impact Estimate 0.0658
- REVEL 0.01
- MetaLR 0.03
- MetaSVM -0.99
- CADD 1.13
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the South Asian population (allele frequency 0.00013)
- Structural context available