C63Y (p.Cys63Tyr) variant of ICOS (Inducible T-cell costimulator)
C63Y (p.Cys63Tyr) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
C63Y (p.Cys63Tyr) variant details
- p.Cys63Tyr
- Ensembl rs1690066694
- Missense
- Variant Prioritization Score for Impact Estimate 0.44
- REVEL 0.26
- MetaLR 0.19
- MetaSVM -0.63
- CADD 24.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available