C63S (p.Cys63Ser) variant of ICOS (Inducible T-cell costimulator)
C63S (p.Cys63Ser) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, published literature, and structural context.
C63S (p.Cys63Ser) variant details
- p.Cys63Ser
- gnomAD 2-203955764-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.411
- REVEL 0.30
- MetaLR 0.18
- MetaSVM -0.56
- CADD 24.50
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available