C12F (p.Cys12Phe) variant of ICOS (Inducible T-cell costimulator)
C12F (p.Cys12Phe) in ICOS (Inducible T-cell costimulator) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, published literature, and structural context.
C12F (p.Cys12Phe) variant details
- p.Cys12Phe
- gnomAD 2-203936849-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.326
- REVEL 0.28
- MetaLR 0.35
- MetaSVM -0.08
- CADD 24.20
- PolyPhen-2 0.74
- SIFT 0.02
- Population evidence available
- Structural context available
- Literature evidence available