V8A (p.Val8Ala) variant of IAPP (Islet amyloid polypeptide)
V8A (p.Val8Ala) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
V8A (p.Val8Ala) variant details
- p.Val8Ala
- TOPMed rs1416344280
- gnomAD rs1416344280
- Missense
- Variant Prioritization Score for Impact Estimate 0.345
- REVEL 0.14
- CADD 10.20
- PolyPhen-2 0.01
- SIFT 0.24
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available