V12L (p.Val12Leu) variant of IAPP (Islet amyloid polypeptide)
V12L (p.Val12Leu) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data, published literature, and structural context.
V12L (p.Val12Leu) variant details
- p.Val12Leu
- gnomAD 12-21373385-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.0834
- REVEL 0.09
- CADD 1.97
- PolyPhen-2 0.03
- SIFT 0.19
- Population evidence available
- Structural context available
- Literature evidence available