T42K (p.Thr42Lys) variant of IAPP (Islet amyloid polypeptide)
T42K (p.Thr42Lys) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
T42K (p.Thr42Lys) variant details
- p.Thr42Lys
- ExAC rs761079012
- TOPMed rs761079012
- gnomAD rs761079012
- Missense
- Variant Prioritization Score for Impact Estimate 0.331
- REVEL 0.26
- CADD 18.20
- PolyPhen-2 0.81
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available