T23K (p.Thr23Lys) variant of IAPP (Islet amyloid polypeptide)
T23K (p.Thr23Lys) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, published literature, and structural context.
T23K (p.Thr23Lys) variant details
- p.Thr23Lys
- gnomAD 12-21373419-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.286
- REVEL 0.11
- CADD 15.80
- PolyPhen-2 0.17
- SIFT 0.16
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available