S27R (p.Ser27Arg) variant of IAPP (Islet amyloid polypeptide)
S27R (p.Ser27Arg) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
S27R (p.Ser27Arg) variant details
- p.Ser27Arg
- ExAC rs780362061
- TOPMed rs780362061
- gnomAD rs780362061
- Missense
- Variant Prioritization Score for Impact Estimate 0.169
- REVEL 0.12
- CADD 22.40
- PolyPhen-2 0.87
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available