S14Y (p.Ser14Tyr) variant of IAPP (Islet amyloid polypeptide)
S14Y (p.Ser14Tyr) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
S14Y (p.Ser14Tyr) variant details
- p.Ser14Tyr
- cosmic curated COSV99557
- Missense
- Variant Prioritization Score for Impact Estimate 0.316
- REVEL 0.31
- CADD 13.10
- PolyPhen-2 0.40
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available