R33W (p.Arg33Trp) variant of IAPP (Islet amyloid polypeptide)
R33W (p.Arg33Trp) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
R33W (p.Arg33Trp) variant details
- p.Arg33Trp
- TOPMed rs1370833713
- gnomAD rs1370833713
- Missense
- Variant Prioritization Score for Impact Estimate 0.203
- REVEL 0.18
- CADD 23.10
- PolyPhen-2 0.11
- SIFT 0.00
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available