R33P (p.Arg33Pro) variant of IAPP (Islet amyloid polypeptide)
R33P (p.Arg33Pro) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
R33P (p.Arg33Pro) variant details
- p.Arg33Pro
- ExAC rs200996235
- TOPMed rs200996235
- gnomAD rs200996235
- Missense
- Variant Prioritization Score for Impact Estimate 0.348
- REVEL 0.34
- CADD 26.00
- PolyPhen-2 0.96
- SIFT 0.00
- Most common in the East Asian population (allele frequency 0.00038)
- Structural context available