P24L (p.Pro24Leu) variant of IAPP (Islet amyloid polypeptide)
P24L (p.Pro24Leu) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, published literature, and structural context.
P24L (p.Pro24Leu) variant details
- p.Pro24Leu
- gnomAD 12-21373422-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.223
- REVEL 0.16
- CADD 16.30
- PolyPhen-2 0.03
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available