N18D (p.Asn18Asp) variant of IAPP (Islet amyloid polypeptide)
N18D (p.Asn18Asp) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
N18D (p.Asn18Asp) variant details
- p.Asn18Asp
- gnomAD rs1262493141
- Missense
- Variant Prioritization Score for Impact Estimate 0.114
- REVEL 0.06
- CADD 9.69
- PolyPhen-2 0.09
- SIFT 0.11
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available