L6M (p.Leu6Met) variant of IAPP (Islet amyloid polypeptide)
L6M (p.Leu6Met) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
L6M (p.Leu6Met) variant details
- p.Leu6Met
- TOPMed rs1368478122
- Missense
- Variant Prioritization Score for Impact Estimate 0.33
- REVEL 0.34
- CADD 20.40
- PolyPhen-2 0.98
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available