L45P (p.Leu45Pro) variant of IAPP (Islet amyloid polypeptide)
L45P (p.Leu45Pro) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data and structural context.
L45P (p.Leu45Pro) variant details
- p.Leu45Pro
- gnomAD rs1484149172
- Missense
- Variant Prioritization Score for Impact Estimate 0.656
- REVEL 0.69
- CADD 27.10
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available