L20P (p.Leu20Pro) variant of IAPP (Islet amyloid polypeptide)
L20P (p.Leu20Pro) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
L20P (p.Leu20Pro) variant details
- p.Leu20Pro
- ExAC rs758292552
- gnomAD rs758292552
- Missense
- Variant Prioritization Score for Impact Estimate 0.532
- REVEL 0.63
- CADD 24.20
- PolyPhen-2 1.00
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available