L13P (p.Leu13Pro) variant of IAPP (Islet amyloid polypeptide)
L13P (p.Leu13Pro) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
L13P (p.Leu13Pro) variant details
- p.Leu13Pro
- ExAC rs754564502
- TOPMed rs754564502
- gnomAD rs754564502
- Missense
- Variant Prioritization Score for Impact Estimate 0.495
- REVEL 0.56
- CADD 15.40
- PolyPhen-2 0.07
- SIFT 0.08
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available