K32E (p.Lys32Glu) variant of IAPP (Islet amyloid polypeptide)
K32E (p.Lys32Glu) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, published literature, and structural context.
K32E (p.Lys32Glu) variant details
- p.Lys32Glu
- gnomAD 12-21378250-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.407
- REVEL 0.27
- CADD 25.70
- PolyPhen-2 0.81
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available