I3T (p.Ile3Thr) variant of IAPP (Islet amyloid polypeptide)
I3T (p.Ile3Thr) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, published literature, and structural context.
I3T (p.Ile3Thr) variant details
- p.Ile3Thr
- gnomAD 12-21373359-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.283
- REVEL 0.30
- CADD 4.44
- PolyPhen-2 0.00
- SIFT 0.33
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available