I3F (p.Ile3Phe) variant of IAPP (Islet amyloid polypeptide)
I3F (p.Ile3Phe) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
I3F (p.Ile3Phe) variant details
- p.Ile3Phe
- gnomAD rs1161915805
- Missense
- Variant Prioritization Score for Impact Estimate 0.148
- REVEL 0.18
- CADD 7.15
- PolyPhen-2 0.09
- SIFT 0.02
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available