I25T (p.Ile25Thr) variant of IAPP (Islet amyloid polypeptide)
I25T (p.Ile25Thr) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
I25T (p.Ile25Thr) variant details
- p.Ile25Thr
- TOPMed rs1939946378
- Missense
- Variant Prioritization Score for Impact Estimate 0.215
- REVEL 0.16
- CADD 8.23
- PolyPhen-2 0.00
- SIFT 0.28
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available