I25H (p.Ile25His) variant of IAPP (Islet amyloid polypeptide)
I25H (p.Ile25His) in IAPP (Islet amyloid polypeptide) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, published literature, and structural context.
I25H (p.Ile25His) variant details
- p.Ile25His
- gnomAD 12-21373420-A-AC
- Frameshift
- Variant Prioritization Score for Impact Estimate 0.239
- CADD 22.40
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available