G2S (p.Gly2Ser) variant of IAPP (Islet amyloid polypeptide)
G2S (p.Gly2Ser) in IAPP (Islet amyloid polypeptide) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
G2S (p.Gly2Ser) variant details
- p.Gly2Ser
- cosmic curated COSV10587
- ExAC rs557866734
- TOPMed rs557866734
- gnomAD rs557866734
- Missense
- Variant Prioritization Score for Impact Estimate 0.123
- REVEL 0.13
- CADD 6.55
- PolyPhen-2 0.01
- SIFT 0.36
- Most common in the HGDP:YAKUT population (allele frequency 0.08)
- Structural context available