W21L (p.Trp21Leu) variant of HTR2C (5-hydroxytryptamine receptor 2C)
W21L (p.Trp21Leu) in HTR2C (5-hydroxytryptamine receptor 2C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, published literature, and structural context.
W21L (p.Trp21Leu) variant details
- p.Trp21Leu
- gnomAD X-114731320-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.413
- REVEL 0.24
- MetaLR 0.23
- MetaSVM -0.69
- CADD 25.80
- PolyPhen-2 0.99
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available