V27L (p.Val27Leu) variant of HTR2C (5-hydroxytryptamine receptor 2C)
V27L (p.Val27Leu) in HTR2C (5-hydroxytryptamine receptor 2C) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
V27L (p.Val27Leu) variant details
- p.Val27Leu
- NCI-TCGA Cosmic COSV9934
- cosmic curated COSV99349
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.138
- REVEL 0.03
- MetaLR 0.07
- MetaSVM -1.03
- CADD 13.70
- PolyPhen-2 0.06
- SIFT 0.36
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available