V27G (p.Val27Gly) variant of HTR2C (5-hydroxytryptamine receptor 2C)
V27G (p.Val27Gly) in HTR2C (5-hydroxytryptamine receptor 2C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data, published literature, and structural context.
V27G (p.Val27Gly) variant details
- p.Val27Gly
- gnomAD X-114731338-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.15
- MetaLR 0.21
- MetaSVM -0.73
- CADD 23.60
- PolyPhen-2 0.64
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- Literature evidence available