S59T (p.Ser59Thr) variant of HTR2C (5-hydroxytryptamine receptor 2C)
S59T (p.Ser59Thr) in HTR2C (5-hydroxytryptamine receptor 2C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
S59T (p.Ser59Thr) variant details
- p.Ser59Thr
- ExAC rs781896215
- TOPMed rs781896215
- gnomAD rs781896215
- Missense
- Variant Prioritization Score for Impact Estimate 0.11
- REVEL 0.06
- MetaLR 0.05
- MetaSVM -1.06
- CADD 10.50
- PolyPhen-2 0.03
- SIFT 0.04
- Most common in the Ashkenazi Jewish population (allele frequency 5.2e-05)
- Structural context available