S26F (p.Ser26Phe) variant of HTR2C (5-hydroxytryptamine receptor 2C)
S26F (p.Ser26Phe) in HTR2C (5-hydroxytryptamine receptor 2C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
S26F (p.Ser26Phe) variant details
- p.Ser26Phe
- cosmic curated COSV10637
- Missense
- Variant Prioritization Score for Impact Estimate 0.34
- REVEL 0.12
- MetaLR 0.15
- MetaSVM -0.91
- CADD 23.70
- PolyPhen-2 0.70
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3.3e-05)
- Structural context available