P29T (p.Pro29Thr) variant of HTR2C (5-hydroxytryptamine receptor 2C)
P29T (p.Pro29Thr) in HTR2C (5-hydroxytryptamine receptor 2C) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
P29T (p.Pro29Thr) variant details
- p.Pro29Thr
- NCI-TCGA Cosmic COSV9935
- cosmic curated COSV99351
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.337
- REVEL 0.18
- MetaLR 0.17
- MetaSVM -0.90
- CADD 21.80
- PolyPhen-2 1.00
- SIFT 0.53
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available