L15I (p.Leu15Ile) variant of HTR2C (5-hydroxytryptamine receptor 2C)
L15I (p.Leu15Ile) in HTR2C (5-hydroxytryptamine receptor 2C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, published literature, and structural context.
L15I (p.Leu15Ile) variant details
- p.Leu15Ile
- gnomAD X-114731301-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.282
- REVEL 0.11
- MetaLR 0.18
- MetaSVM -0.69
- CADD 24.20
- PolyPhen-2 0.99
- SIFT 0.03
- Population evidence available
- Structural context available
- Literature evidence available