G51R (p.Gly51Arg) variant of HTR2C (5-hydroxytryptamine receptor 2C)
G51R (p.Gly51Arg) in HTR2C (5-hydroxytryptamine receptor 2C) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
G51R (p.Gly51Arg) variant details
- p.Gly51Arg
- cosmic curated COSV10959
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.295
- REVEL 0.20
- MetaLR 0.03
- MetaSVM -1.02
- CADD 22.60
- PolyPhen-2 1.00
- SIFT 0.16
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3.8e-05)
- Structural context available