Y137F (p.Tyr137Phe) variant of HTR2A (5-hydroxytryptamine receptor 2A)
Y137F (p.Tyr137Phe) in HTR2A (5-hydroxytryptamine receptor 2A) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, published literature, and structural context.
Y137F (p.Tyr137Phe) variant details
- p.Tyr137Phe
- gnomAD 13-46895497-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.292
- REVEL 0.10
- MetaLR 0.04
- MetaSVM -1.05
- CADD 24.20
- PolyPhen-2 0.10
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available