W141R (p.Trp141Arg) variant of HTR2A (5-hydroxytryptamine receptor 2A)
W141R (p.Trp141Arg) in HTR2A (5-hydroxytryptamine receptor 2A) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes population frequency data and structural context.
W141R (p.Trp141Arg) variant details
- p.Trp141Arg
- gnomAD rs1330614688
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.778
- REVEL 0.83
- MetaLR 0.81
- MetaSVM 0.94
- CADD 31.00
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available