R140W (p.Arg140Trp) variant of HTR2A (5-hydroxytryptamine receptor 2A)
R140W (p.Arg140Trp) in HTR2A (5-hydroxytryptamine receptor 2A) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
R140W (p.Arg140Trp) variant details
- p.Arg140Trp
- cosmic curated COSV10891
- TOPMed rs962495795
- gnomAD rs962495795
- Missense
- Variant Prioritization Score for Impact Estimate 0.436
- REVEL 0.43
- MetaLR 0.41
- MetaSVM -0.18
- CADD 26.80
- PolyPhen-2 0.67
- SIFT 0.06
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available